Other Cephalosporins: What They Are and When They're Used
Cephalosporins are a big family of antibiotics. Most people know Keflex (cephalexin). This page looks at the other cephalosporins — the ones doctors reach for when Keflex isn't the best fit. You’ll read about common names, typical uses, safety points, and quick tips for talking with your doctor or pharmacist.
Common drugs and why doctors choose them
Cephalosporins are grouped by generation. Each generation changes how well the drug fights certain bacteria and how it’s given (pill vs. injection).
Second generation: cefuroxime — often used for sinus infections, bronchitis, ear infections, and some skin infections. It’s available as an oral tablet and as an injection.
Third generation: cefixime (oral) and ceftriaxone (injection). Cefixime is used for some urinary and respiratory infections. Ceftriaxone treats more serious infections like meningitis, severe pneumonia, and gonorrhea — it’s given in hospital settings.
Fourth generation: cefepime — a hospital antibiotic for drug-resistant or severe infections. It’s stronger against certain gram-negative bacteria.
Advanced options: ceftaroline — one of the few cephalosporins active against MRSA. It’s used when MRSA or complicated skin infections are involved.
What to watch for & practical tips
Allergy: a lot of people say they’re allergic to penicillin. Most modern research shows true cross-reaction with cephalosporins is low (around 1% or less), especially with later-generation drugs. Still, always tell your clinician about any past reactions — rashes, breathing trouble, or swelling — not just "I don’t like it."
Side effects: common ones are stomach upset, diarrhea, and yeast infections. Serious reactions are rare but need urgent care — hives, swelling, trouble breathing, or severe diarrhea with fever.
Resistance and proper use: antibiotics only work on bacteria, not viruses. Don’t use cephalosporins for colds or most sore throats unless a doctor confirms a bacterial cause. Finish the full course unless your doctor says otherwise. Stopping early can encourage resistant bacteria.
Drug interactions and dosing: some cephalosporins interact with blood thinners and other meds. Kidney function affects dosing for many drugs. If you have kidney problems or take multiple medicines, ask for a dosing check.
Buying and saving: prices vary a lot. Generic versions are usually cheaper. If you’re buying from a Mexican pharmacy or comparing online, check the exact drug name and dose. Ask the pharmacist to confirm authenticity and expiration dates.
Final tip: if your infection isn’t improving in 48–72 hours on an antibiotic, call your provider. That may mean the bacteria aren’t sensitive to the drug or a different diagnosis is needed.
Need help comparing prices or finding alternatives to Keflex? Use our site tools to compare Mexican pharmacy prices and read our treatment guides before you buy.
